Our Projects


ADAPTABLE Research Summary

Investigator: Drs. Matthew T. Roe, MD, MHS, Duke Clinical Research Institute

Purpose: ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness)  is a three-year pragmatic clinical trial that will compare the effectiveness of two different daily doses of aspirin widely used to prevent heart attacks and strokes in individuals living with heart disease. Pragmatic trials are designed to reflect “real-world” medical care by recruiting broad populations of patients, embedding the trial into the usual healthcare setting, and leveraging data from health systems to produce results that can be readily used to improve patient care.

Goal: To study which aspirin dose is best to protect patients with heart disease

About this study:

Results of this study will help patients and their caregivers answer questions like:

  • How much aspirin should I take each day to reduce my risk of another heart attack or stroke?
  • Do the bene ts of taking aspirin every day differ based on the dose?
  • Do the risks differ base on the dose?
  • Based on my health, age, and other circumstances, what’s the best dose to protect my health?

How to participate:

The ADAPTABLE study will enroll and follow as many as 20,000 patients with heart disease. Eligible participants in ADAPTABLE will be identified from large health systems that are part of PCORnet’s Clinical Data Research Networks (CDRNs).

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